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Patel, Ravi N.
- Latest Strategy of Medicinal Chemistry Implements In-silico After In-Vivo and In-Vitro
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana- 384001, Gujarat, IN
2 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana- 384001, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 2 (2011), Pagination: 167-180Abstract
The inner eye of chemistry looks forward to the biology for getting the best output to design a potent drug molecule after crossing the iron gates of pharmacological as well as clinical trials. The basic scientific research in pharmacy is blooming in the impact of the compatibility of designed chemical molecule towards biological molecule. Latest technology in pharmaceutical science reflects the implementation of new methodologies to screen a new chemical entity in a biological system. The inner eye of chemistry looks forward to the biology for getting the best output to design a potent drug molecule after crossing the iron gates of pharmacological as well as clinical trials. The basic scientific research in pharmacy is blooming in the impact of the compatibility of designed chemical molecule towards biological molecule. Latest technology in pharmaceutical science reflects the implementation of new methodologies to screen a new chemical entity in a biological system. A representative problem in bioinformatics is the assembly of high-quality genome sequences from fragmentary "shotgun" DNA sequencing. Other common problems include the study of gene to perform expression profiling using data from microarrays or mass spectrometry. Framing the structural framework of a chemical molecule is first done by in-silico by computational chemistry and that is synthesized by in-situ method. This after synthesis the biological screening is done by both in-vitro and in-vivo studies to enlist as a potent moiety by QSAR. All these newer techniques possess a prefix “In” for in-vitro, in-vivo, in-situ and in-silico which are the In-ner eye of the members of pharmaceutical research.
Keywords
Optimization, Molecular Dynamics, Monte Carlo, Replica Exchange Method, Quantum Mechanics, In-Vitro, In-Vivo, In-Situ, In-Papyro and In-Silico.
- Synthesis and Antibacterial Study of Some New Schiff's Bases of 2- Hydrazinyl-1-(1H-Imidazole-1-yl)-Ethanone
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Hemchandracharya North Gujarat University, Arvind Baug, Mehsana-384001, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 55-57Abstract
Imidazole on reaction with chloroacetyl chloride afford 2-chloro-1-(1H-imidazole-1-yl)-ethanone, 1 which on treatment with hydrazine hydrate has yielded 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone, 2. Condensation of 2 with various aromatic aldehydes afforded sustituted Schiff’s base of 2-hydrazinyl-1-(1H-imidazol-1-yl)-ethanone. The structures of all the products were characterized on the basis of their IR, Mass and 1H-NMR spectroscopic data analysis. All the synthesised products were screened for their antibacterial activity against gram-positive and gram negative bacteria by cup-plate method.
Keywords
Synthesis, Imidazole, Aromatic Aldehydes, Schiff’s Bases, Antibacterial Activity.- Foldamers are Artificial Molecular Architectures Inspired by Biopolymers Which can hold the Molecules in the Matrix by Non-Covalent Interactions
Authors
1 Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 13-23Abstract
Biological macromolecules are composed of one or more linear oligomers that fold into a functional form. The information that governs the final structure is encoded in the sequence of monomers and the precise functionality that they display, but accurate prediction of such structures remains a major challenge in structural biology. Recently, chemists have begun to develop small molecule systems that fold in a similar way and these may help to answer more complex questions or find applications in artificial molecular assemblies. Study of the properties of a family of oligoamides composed of alternating repeats of isophthalic acid and bisaniline building blocks have a rich supramolecular chemistry in non-polar solvents, forming macrocyclic receptors, catenanes, knots and double-stranded zipper complexes via a combination of amide–amide hydrogen bonds and aromatic interactions. Here the serendipitous discovery of a new member of the family that folds into a well-defined, compact, three-dimensional structure, governed by a combination of hydrogen bonding and aromatic interactions.